The Utilizing Health Information for Meaningful Impact in East Africa through Data Science (UZIMA-DS) Research Hub is a state-of-the-art, scalable, and sustainable platform dedicated to the application of advanced data assimilation techniques and novel artificial intelligence and machine learning methodologies. The core objective of the hub is to develop early warning systems designed to significantly improve health outcomes for young Africans, with a special focus on maternal, newborn, and child health as well as mental health.